Jay SJ Hong

Postdoctoral Scholar

Graduated from the Faculty of Pharmacy at University of Sydney and then went onto study in the Interdisciplinary Program in Biochemical Engineering and Biotechnology at Seoul National University. After receiving a phD degree in the year 2008, I joined the Systems Biology Research Group to apply a systems approach to the study of 'Pathogenic Microorganisms.'

Education

2008, Ph.D. Interdisciplinary Program in Biochemical Engineering and Biotechnology, Seoul National University, Republic of Korea (Advisor: Professor Cha Yong Choi)

2002, M.Eng. Interdisciplinary Program in Biochemical Engineering and Biotechnology, Seoul National University, Republic of Korea (Advisor: Professor Cha Yong Choi)

2000, B.Pharm. Faculty of Pharmacy, University of Sydney, Australia

Publications

J.W. Park#, J.S.J. Hong#, N. Parajuli, W.S. Jung, S.R. Park, S.K. Lim, J.K. Sohng and Y.J. Yoon. (2008) Genetic dissection of the biosynthetic route to gentamicin A2 by heterologous expression of its minimal gene set. Proc Natl Acad Sci USA. 105, 8399-8404. (#co-author)

W.S. Jung, A.R. Han, J.S.J. Hong, S.R. Park, C.Y. Choi, J.W. Park and Y.J. Yoon. (2007) Bioconversion of 12-, 14-, and 16-membered ring aglycones to glycosylated macrolides in an engineered strain of Streptomyces venezuelae. Appl Microbiol Biotechnol. 76, 1373-1381.

J.W.1 Park, J.S.J. Hong, N. Parajuli, H.S. Koh, S.R. Park, M.O. Lee, S.K. Lim and Y.J. Yoon. (2007) Analytical profiling of biosynthetic intermediates involved in the gentamicin pathway of Micromonospora echinospora by high-performance liquid chromatography using electrospray ionization mass spectrometric detection. Anal Chem. 79, 4860-4869.

J.S.J. Hong#, S.J. Park#, N. Parajuli, S.R. Park, H.S. Koh, W.S. Jung, C.Y. Choi and Y.J. Yoon. (2007) [Functional analysis of DesVIII homologues involved in glycosylation of macrolide antibiotics by interspecies complementation]. Gene, 386, 123-130. (#co-author) (http://www.sciencedirect.com/science/article/pii/S0378111906005762)

X. Qi, E.J. Jun, L. Xu, S.J. Kim, J.S.J. Hong, Y.J. Joon and J.Y. Yoon. (2006) New BODIPY as OFF-ON fluroescent chemosensor and flurescent chemodosimeter for Cu2+: Cooperative selectivity enhancement toward Cu2+. J Org Chem. 71, 2881-2884.

Y.J. Jang, B.S. Moon, M.S. Park, B.G. Kang, J.Y. Kwon, J.S.J. Hong, Y.J. Yoon, K.D. Lee and J.Y. Yoon. (2006) New cavitand derivatives bearing four coumarin groups as fluorescent chemosensors for Cu2+ and recognition of dicarboxylates utilizing Cu2+ complex. Tetrahedron Lett. 47, 2707-2710.

S.K. Lee, J.S.J. Hong, C.Y. Choi, J.S. Ahn and Y.J. Yoon. (2006) Enhanced production of hydroxyled macrolides from the pikromycin pathway of Streptomyces venezuelae. Enzyme Microb Technol. 39, 778-782.

J.W. Seok, S.K. Lee, J.S.J. Hong, S.R. Park, S.J. Jeong, A.R. Han, J.K. Sohng, B.G. Kim, C. Y. Choi, D.H. Sherman and Y.J. Yoon. (2006) Heterologous expression of tylosin polyketide synthase and production of a hybrid bioactive macrolide in Streptomyces venezuelae. Appl Microbiol Biotechnol. 72, 763-769.

J.S.J. Hong, W.S. Jung, S.K. Lee, H.S. Koh, H.S. Park, S.J. Park, Y.S. Kim, and Y.J. Yoon. (2005) The role of a second protein (DesVIII) in Glycosylation for the biosynthesis of hybrid macrolide antibiotics in Streptomyces venezuelae. J Microbiol Biotechnol. 15, 640-645.

S.K. Lee, D.B. Basnet, J.S.J. Hong, W.S. Jung, C.Y. Choi, H.C. Lee, J.K. Sohng, K.G. Ryu, D. J. Kim, J.S. Ahn, B.S. Kim, H.C. Oh, D.H. Sherman and Y.J. Yoon. (2005) Structural diversification of macrolactones by substrate-flexible cytochrome P450 monooxygenases. Adv Synth Catal. 347, 1369-1378.

J.S.J. Hong, S.H. Park, C.Y. Choi, J.K. Sohng and Y.J. Yoon. (2004) New olivosyl derivatives of methymycin/pikromycin from an engineered strain of Streptomyces venezuelae. FEMS Microbiol Lett. 238, 391-399.

J.S.J. Hong, C.Y. Choi and Y.J. Yoon. (2003) Premature release of polyketide intermediates by Hybrid polyketide synthase in Amycolatopsis mediterranei S699. J Microbiol Biotechnol. 13, 613-619.

Contact Information

Email Address: jahong@ucsd.edu

Phone: (858) 922-6749

Mailing Address: 9500 Gilman Drive Mail Code 0412 La Jolla, CA 92093-0412

Location

Location

417 Powell-Focht Bioengineering Hall

9500 Gilman Drive La Jolla, CA 92093-0412

Contact Us

Contact Us

In Silico Lab:  858-822-1144

Wet Lab:  858-246-1625

FAX:   858-822-3120

Website Concerns: sbrgit@ucsd.edu

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