Adam M. Feist

Project Scientist

July 2010 – present

Grants and Awards

  • PI - Agency: Novo Nordisk Foundation - Focus: Automated Adaptive Laboratory Evolution (ALE) technology development
  • Co-PI - Agency: Novo Nordisk Foundation - Focus: Network Reconstruction and in silico Biology
  • Co-I - Agency: NIH - Focus: Systems biology targeting of antimicrobial resistance Project Description


Key Selected Publications

  • Sandberg TE, Lloyd CJ, Palsson BO, Feist AM, “Laboratory Evolution to Alternating Substrate Environments Yields Distinct Phenotypic and Genetic Adaptive Strategies.” Appl Environ Microbiol. Apr 28. pii: AEM.00410-17. doi: 10.1128/AEM.00410-17. (2017)

  • LaCroix RA, Palsson BO, Feist AM “A Model for Designing Adaptive Laboratory Evolution Experiments.” Appl Environ Microbiol. Mar 31;83(8). pii: e03115-16. doi: 10.1128/AEM.03115-16 (2017)

  • Monk JM, Koza A, Campodonico MA, Machado D, Seoane JM, Palsson BO, Herrgård MJ, Feist AM. Multi-omics quantification of species variation of Escherichia coli links molecular features with strain phenotypes. Cell Systems. Sept 28;3(3):238-51. (2016)

  • Guzman GI, Utrilla J, Brunk E, Monk JM, Ebrahim A, Nurk S, Palsson BO, Feist A.M. "Model-driven discovery of underground metabolic functions in Escherichia coli." Proc Natl Acad Sci U S A. 112(3):929-34. (2015)

  • LaCroix RA, Sandberg TE, O'Brien EJ, Utrilla J, Ebrahim A, Guzman GI, Szubin R, Palsson BO, Feist A.M. “Discovery of key mutations enabling rapid growth of Escherichia coli K-12 MG1655 on glucose minimal media using adaptive laboratory evolution.” Applied and Environmental Biology, 18(1):17-30 (2015)

  • Campodonico MA, Andrews BA, Asenjo JA, Palsson BO, Feist A.M. “Generation of an atlas for commodity chemical production in Escherichia coli and a novel pathway prediction algorithm, GEM-Path.” Metabolic Engineering 25:140-58 (2014)

Google Scholar

Research Focuses and Skills:

  • Adaptive Laboratory Evolution (ALE) - Supervises and leads the design, development, and implementation of over $1M of automated equipment for ALE studies, and a bioinformatics-driven mutational database
  • Constraint-based Modeling and Reconstruction (COBRA): Major contributor to the field through model building, algorithm development, applied studies, and experimental validation
  • Runs day-to-day operations of the Systems Biology Research Group including managing budgets and wet lab
  • Serves as Research Advisor and Thesis Committee Member for numerous graduate students in the department of Bioengineering, as well as mentoring Post-docs and Undergraduate students


Doctor of Philosophy in Bioengineering University of California - San Diego, December 2008

Master of Science in Bioengineering University of California - San Diego, December 2005

Bachelor of Science in Chemical Engineering University of Nebraska - Lincoln, May 2003, Honors Program Graduate

Previous Research Experience

GT Life Sciences, Inc., San Diego, CA (2009 - 2010)

Biological Process Development Facility / UNL - Protein Purification Laboratory (2002 - 2003)

Goodyear Inc., Lincoln, Nebraska - Co-Op Participant (2001 - 2002)

Research Experience for Undergraduates Program (REU) / Colorado State University (Summer 2001)

Contact Information

Email Address:

Phone: (858) 534-9592

Mailing Address: 9500 Gilman Drive, Mail Code 0412, La Jolla, CA 92093-0412



417 Powell-Focht Bioengineering Hall

9500 Gilman Drive La Jolla, CA 92093-0412

Contact Us

Contact Us

In Silico Lab:  858-822-1144

Wet Lab:  858-246-1625

FAX:   858-822-3120

Website Concerns:


Visit the Official SBRG YouTube Channel

User Login